Найкращі діагности з МРТ головного мозку в Туреччині – ТОП-52 лікарі

Medical School: Suleyman Demirel University, 2004 

Neurosurgery Training: Gazi University, Department of Neurosurgery, 2011 

H index: 10, I10 Index: 12 Citations: 296

 Dr Mehmet Tonge has international and nationwide 32 publications, 12 book chapters, 92 oral and poster presentations and 41 invited lectures, mostly on Stereotactic and Functional Neurosurgery. 

Work & Training experience:

2004-2011: Gazi University, Department of Neurosurgery (Residency)

 2008: Zurich University Hospital, Department of Neurosurgery (Intraoperative MRI applications), Switzerland 

2008: Zurich University Hospital, Department of Neurosurgery: Microneurosurgery, white matter dissection, interventional neuroradiology courses, Switzerland 

2011 – 2012: Sinop Ataturk State Hospital, Neurosurgeon

 2012 – 2013: Cankiri State Hospital, Neurosurgeon 

2013 – 2014: Istanbul Medipol University, Department of Neurosurgery & Gamma Knife Center (Ass Prof) 

2013 – now: Maastricht University Neurosurgery & Neuroscience Department (Visiting scientist, PhDc) The Netherlands 

2014: Maastricht University, The Netherlands: Deep Brain Stimulation Fellowship 2014-2018: Istanbul Memorial Hospital Neurosurgery: Staff Neurosurgeon

 2016-2018: Istanbul Florence Nightingale Hospital (Consultant, Gamma Knife Center) 

2018-now: Istanbul Medipol University (Stereotactic & Functional Neurosurgery, Gamma Knife Center) Ass. Prof.) 

Dr Mehmet Tonge has completed 4-year cycle EANS (European Association of Neurosurgical Societies) Training courses. 

Clinical areas of interest:

 • Stereotactic & Functional Neurosurgery

 • Surgery for movement disorders

 • Gamma Knife Radiosurgery 

• Surgery for pain & spasticity 

• Psychosurgery

Research areas of interest: 

• Deep brain stimulation

 • Stereotactic radiosurgery 

Administrative duties:

 • Turkish Neurosurgical Society, Sterotactic & Functional Neurosurgery Section: Board member 2015- 2017 

• Turkish Neurosurgical Society, Sterotactic & Functional Neurosurgery Section: Board member (Secretary) 2017-2019

 • Turkish Skull Base Society: Board member 2016-2018

 • Turkish Skull Base Society: Supervisory board member 2018-2020

 • Deep Brain Stimulation and Movement Disorders Surgery Society: Executive Board Member, (Accountant) 2023-still 

Memberships: 

• WSSFN (World Stereotactic & Functional Neurosurgery Society) 

• ESSFN (European Stereotactic & Functional Neurosurgery Society)

 • Deep Brain Stimulation and Movement Disorders Surgery Society

 • Deep Brain Stimulation Society 

• International Stereotactic Radiosurgery Society 

• Leksell Gamma Knife Society 

• EANS (European Association of Neurosurgical Societies) 

• Turkish Neurosurgical Society

• Turkish Skull Base Society

Sample Publications: 

1. Tonge M. Technological developments in electric based DBS. Deep Brain Stimulation 2024 4(36-41) DOI: https://doi.org/10.1016/j.jdbs.2023.12.001 

2. Akgul E, Onan HB, Islek I, Tonge M, Durmus Y, Barburoglu M, Azizova A, Erol C, Hakyemez B, Sencer S, Aydin K, Arat A. Flow diverter stents in the treatment of recanalized intracranial aneurysms. Interv Neuroradiol. 2021 Aug;27(4):481-489. doi: 10.1177/1591019921990507. Epub 2021 Jan 28. PMID: 33509011; PMCID: PMC8580529. 

3. Mulders AEP, Temel Y, Tonge M, Schaper FLWVJ, van Kranen-Mastenbroek V,Ackermans L, Kubben P, Janssen MLF, Duits A. The association between surgical characteristics and cognitive decline following deep brain stimulation of the subthalamic nucleus in Parkinson's disease. Clin Neurol Neurosurg. 2021 Jan;200:106341. doi: 10.1016/j.clineuro.2020.106341. Epub 2020 Nov 3. PMID: 33160716. 

4. Wetzelaer P, Vlis T, Tonge M, Ackermans L, Kubben P, Evers S, Kocabicak E, Temel Y. Management of Hardware Related Infections after DBS Surgery: A Cost Analysis. Turk Neurosurg. 2018;28(6):929- 933. doi: 10.5137/1019-5149.JTN.21511-17.1. PMID: 29465741. 

5. Bedirli N, Emmez G, Ünal Y, Tönge M, Emmez H. Effects of positive end- expiratory pressure on intracranial pressure during pneumoperitoneum and Trendelenburg position in a porcine mode. Turk J Med Sci. 2017 Nov 13;47(5):1610-1615. doi: 10.3906/sag-1609-17. PMID: 29152942. 

6. Sari R, Tonge M, Bolukbasi FH, Onoz M, Baskan O, Silav G, Elmaci I. Management of Failed Cranioplasty. Turk Neurosurg. 2017;27(2):201-207. doi: 10.5137/1019-5149.JTN.15395-15.0. PMID: 27593759. 

7. Tonge M, Kocabicak E, Ackermans L, Kuijf M, Temel Y. Final Electrode Position in Subthalamic Nucleus Deep Brain Stimulation Surgery: A Comparison of Indirect and Direct Targeting Methods. Turk Neurosurg. 2016;26(6):900-903. doi: 10.5137/1019-5149.JTN.13739-14.1. PMID: 27337232. 

8. Tonge M, Ackermans L, Kocabicak E, van Kranen-Mastenbroek V, Kuijf M, Oosterloo M, Kubben P, Temel Y. A detailed analysis of intracerebral hemorrhages in DBS surgeries. Clin Neurol Neurosurg. 2015 Dec;139:183-7. doi: 10.1016/j.clineuro.2015.10.017. Epub 2015 Oct 23. PMID: 26513430. 

9. Silav G, Bölükbaşı FH, Özek E, Tönge M, Önöz M, Elmacı İ. A Simple Technique for Bone Storage after Decompressive Craniectomy in Children. Pediatr Neurosurg. 2015;50(3):161-4. doi: 10.1159/000381748. Epub 2015 May 14. PMID: 25998533. 

10. Yilmaz MB, Donmez H, Tonge M, Senol S, Tekiner A. Vertebrojugular arteriovenous fistula and pseudoaneurysm formation due to penetrating vertebral artery injury: case report and review of the literature. Turk Neurosurg. 2015;25(1):141-5. doi: 10.5137/1019-5149.JTN.8247-13.1. PMID: 25640560. 

11. Kurt G, Tönge M, Çeltıkçı E, Çapraz I, Serdaroğlu A, Bılır E. Surgery for intractable temporal lobe epilepsy: experience of a single institution. Turk J Med Sci. 2014;44(5):866-70. doi: 10.3906/sag-1307- 30. PMID: 25539559. 

12. Yılmaz MB, Tönge M, Emmez H, Kaymaz F, Kaymaz M. Neuroprotective effects of quetiapine on neuronal apoptosis following experimental transient focal cerebral ischemia in rats. J Korean Neurosurg Soc. 2013 Jul;54(1):1-7. doi: 10.3340/jkns.2013.54.1.1. Epub 2013 Jul 31. PMID: 24044072; PMCID: PMC3772279. 

13. Yilmaz MB, Egemen E, Tonge M, Kaymaz M. Transoral protrusion of a peritoneal catheter due to gastric perforation 10 years after a ventriculoperitoneal shunting: case report and review of the literature. Turk Neurosurg. 2013;23(2):285-8. doi: 10.5137/1019-5149.JTN.4904-11.1. PMID: 23546921. 

14. Omerhodzic I, Tonge M, Matos B, Musabeliu E, Raspanti C, Ferdinandov D, Galimova R, Muroi C, Balik V, Kursumovic A. Neurosurgical training programme in selected European countries: from the young neurosurgeons' point of view. Turk Neurosurg. 2012;22(3):286-93. doi: 10.5137/1019- 5149.JTN.5133-11.0. PMID: 22664994. 

15. Ergun E, Kurt G, Tonge M, Aytar H, Tas M, Baykaner K, Ceviker N. Effects of phenytoin sodium on dura mater healing in a rat model of CSF leakage. Turk Neurosurg. 2011;21(4):471-6. PMID: 22194102. 

16. Emmez H, Tonge M, Tokgoz N, Durdag E, Gonul I, Cevıker N. Radiological and histopathological comparison of microporous polysaccharide hemospheres and oxidized regenerated cellulose in the rabbit brain: a study of efficacy and safety. Turk Neurosurg. 2010 Oct;20(4):485-91. doi: 10.5137/1019- 5149.JTN.3300-10.2. PMID: 20963698. 

17. Emmez H, Yildirim Z, Kale A, Tönge M, Durdağ E, Börcek AO, Uçankuş LN, Doğulu F, Kiliç N, Baykaner MK. Anti-apoptotic and neuroprotective effects of α-lipoic acid on spinal cord ischemiareperfusion injury in rabbits. Acta Neurochir (Wien). 2010 Sep;152(9):1591-600; discussion 1600-1. doi: 10.1007/s00701-010-0703-9. Epub 2010 Jun 10. PMID: 20535507. 

18. Kurt G, Tonge M, Börcek AO, Karahacioglu E, Gurel O, Baykaner K, Ceviker N, Aykol S. Fractionated gamma knife radiosurgery for optic nerve tumors: a technical report. Turk Neurosurg. 2010 Apr;20(2):241-6. doi: 10.5137/1019-5149.JTN.1681-09.3. PMID: 20401852. 

19. Emmez H, Kale A, Tönge M, Cakir A, Ceviker N. Two meningiomas with different histological grades in the same patient. Case report. Neurol Med Chir (Tokyo). 2010;50(8):686-8. doi: 10.2176/nmc.50.686. PMID: 20805656.

Assoc. Prof.  Nesrin Helvacı Yılmaz graduated from Hacettepe University in 2000 as a Medical Doctor.  She completed her specialty training in the Department of Neurology at Ankara University in 2006.

She started her compulsory service in Mardin Nusaybin State Hospital in 2007.  Nesrin Helvacı Yılmaz continued her duty in Gaziantep 27 December State Hospital in 2008.  She worked as a neurologist at Biophysis Nilüfer Medical Center and Ali Osman Sönmez Oncology Hospital in Bursa between 2010-2011, and at Istanbul Universal Aksaray Hospital between 2011-2012. From October 2012, she started to work as a Doctor Lecturer in Istanbul Medipol University Neurology Department.  Nesrin Helvacı Yılmaz received the title of associate professor in 2021.  In 2015, she worked as an Honorary Observer in Parkinson's Disease and Deep Brain Stimulation (Neuromodulation) at UCL Queen Square Institute of Neurology, National Hospital for Neurology in London.  She took part in many training programs on Deep Brain Stimulation (Neuromodulation) in Turkey and abroad between 2013-2022.

Regarding her speciality in Parkinson's disease and movement disorders, she has 5 Tubitak projects, a 2-chapter book , 30 clinical researches and 80 reports presented in domestic and abroad. Assoc. Prof. Nesrin Helvacı Yılmaz, who is still working within the staff of Medipol University, managed the Parkinson's and Movement Disorders Unit of the Department of Neurology during her working time and plans Deep Brain Stimulation therapy applications with the neurosurgical team.

Since September 2018, she has been working as a coordinator for student education in the 5th semester of Neurology. As of December 2022, she has developed treatment plans for patients at Medipol University Istanbul Parkinson's Disease and Movement Disorders Center (PARMER) and provides the most appropriate personal medical follow-up and treatment support for each patient.

PUBLICATIONS

1-Yilmaz N, Yigit A, Akbostanci MC. Clozapine induced epilepsy. Revue Neurologique 2004, Nov;160/11:1093.

2-Nesrin Helvacı Yılmaz, Nursel Aydın. Sıcak Su Epilepsili Bir Olgu. Türkiye Klinikleri Nöroloji Dergisi 2004/Cilt2/Sayı 2.

3-Nesrin Helvacı Yılmaz, Nursel Aydın. Refleks Epilepsiler. Türkiye Klinikleri Nöroloji Dergisi 2004/Cilt2/Sayı 2.

4-Mine Hayriye Sorgun, Bilge Koçer, Funda Kaplan, Nesrin Yılmaz, Nezih Yücemen, Canan Yücesan. Multipl Sklerozda Kraniyal Nöropati. Turk Norol Derg 2011;17:137-142.

5-Nesrin Helvacı Yılmaz, Gökçen Duymaz, Mehmet Akif Yaşar. Parkinson Hastalığı Olan Bir Olguda Malign Sendrom. Turk Norol Derg 2012:18;123-125.

6-Yilmaz NH, Akbostanci MC, Oto A, Aykac O. Prevalence of restless legs syndrome in Ankara, Turkey: an analysis of diagnostic criteria and awareness. Acta Neurol Belg 2012 Oct 31. [Epub ahead of print].

7-Yılmaz NH, Bingol AP. Sensitivity and specificity of Ankara University Cerebral Dominance Inventory in comparison with the Wada test. Acta Neurol Belg 2013 Jun 6 [Epub ahead of print].

8-Sema Demirci, Nesrin Helvacı Yılmaz, Efsun Şenocak, Fatih Han Bölükbaşı. Pons Kavernomu: Kranial Manyetik Rezonans Görüntüleme Bulguları. Turk Norol Derg 2012:19:72.

9-Nesrin Helvacı Yılmaz, Sinem Atik Güngör, Taflan Sahlepçi. Küçük hücreli akciğer kanseri tedavisinde cisplatin kullanımı sırasında gelişen akut iskemik inme: olgu sunumu. J Kartal TR. Baskıdaki Makaleler: KEAH-26937.

POSTERLER:

-Serebral venöz tromboz ve bruselloz Birlikteliği; Olgu Sunumu (42. Ulusal Nöroloji Kongresi-Antalya 2006)

-Waldenström makroglobulinemisine eşlik eden epileptik nöbetler ve nonkonvülsif status epileptikus (42. Ulusal Nöroloji Kongresi-Antalya 2006)

-Prevalence of Restless Legs Syndrome in Ankara, Turkey (16. Uluslararası Parkinson ve Hareket Bozuklukları Kongresi-Dublin 2012).

-Konjenital Miyastenik Sendrom (29. Ulusal Nörofizyoloji EEG-EMG Kongresi- Antalya 2013).

-Beşinci haftada duyusal iletimleri normal olan bir enjeksiyon nöropatisi olgusu (29. Ulusal Nörofizyoloji EEG-EMG Kongresi- Antalya 2013).

-Olgu sunumu: Mononöritis mültipleks ve lepra (29. Ulusal Nörofizyoloji EEG-EMG Kongresi- Antalya 2013).

-İdyopatik Parkinson Hastalığı’nda hızlanmış unutma ve uyku kalitesi (10. Ulusal Parkinson ve Hareket Bozuklukları Kongresi-Antalya 2013).

-Hiperglisemiye bağlı hemikore ve bazal gangliyon hiperintensitesi: Olgu sunumu (10. Ulusal Parkinson ve Hareket Bozuklukları Kongresi-Antalya 2013).

Доктор Тюре розробив поетапний метод навчання користуванню мікроскопом і аспіраційною трубкою. Потім він представив цю техніку нейрохірургічному співтовариству, навчаючи нейрохірургів і відвідуючи міжнародні лабораторії. Він також був президентом 16-го Всесвітнього конгресу нейрохірургії WFNS у Стамбулі, Туреччина, у 2017 році.

Experience

2019 – 2019

• University of Insubria, Varese, Italy, 

Insubria University Faculty of Medicine

2015

• MERSİN UNIVERSITY/FACULTY OF MEDICINE, DOCTOR, LECTURER

2013 – 2015

• ANKARA PRIVATE ACIBADEM HOSPITAL

2010 – 2012

• DIYARBAKIR TRAINING AND RESEARCH HOSPITAL,

2002 – 2003

• AYDIN 1ST PRIVATE TRAINING BATTALION
•  

Education

2010

• ANKARA UNIVERSITY FACULTY OF MEDICINE, BRAIN AND SURGERY SPECIALIST

1992

• GAZI UNIVERSITY, FACULTY OF MEDICINE

PROFESSIONAL EXPERIENCE

2011-2012
Erzurum Koprukoyu State Hospital
Department: General Medicine

2012-2017
Istanbul University Cerrahpaşa Medical Faculty
Department: Internal Medicine

06/2017-10/2017
Istanbul Gaziosmanpasa Taksim Training and Research Hospital
Department: Internal Medicine

10/2017-11/2018
Istanbul University Istanbul Medical Faculty
Department: Allergy and Immunology Fellowship

2018/2022
Istanbul University Oncology Institute
Department: Medical Oncology Fellowship

2022-2023
Tekirdag City Hospital
Department: Medical Oncology Specialist

2023-present
Istanbul Medipol University Medipol Bahcelievler Private Hospital
Department: Medical Oncology Assoc. Prof.

EDUCATION

2005-2011
Medical Education
Sivas Cumhuriyet University Medical Faculty, Sivas, Turkey

2012-2017
Internal Medicine
Istanbul University Cerrahpaşa Medical Faculty, Department of Internal Medicine, Istanbul, Turkey

2017-2018
Allergy-Immunology Fellowship
Istanbul University Istanbul Medical Faculty
Department of Internal Medicine, Division of Allergy and Immunology, Istanbul, Turkey

2018-2022
Medical Oncology Fellowship
Istanbul University Oncology Institute, Department of Medical Oncology, Istanbul, Turkey

2022
ESMO Board Certification in Medical Oncology
10th September 2022 in Paris, France.

2023
Medical Oncology Assoc. Prof.
Istanbul Medipol University Department of Medical Oncology, Istanbul, Turkey

INTERNATIONAL CLINICAL TRIALS:

1. Astefania - ROCHE

• Title: A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
• Role: Subinvestigator

2. PFİZER

• Title: A Study Of Lorlatinib Versus Crizotinib In First-Line Treatment Of Patients With ALK-Positive NSCLC
• Role: Subinvestigator

3. RECITE - AMGEN

• Title: Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Adult Subjects With Gastrointestinal, Pancreatic, or Colorectal Cancer
• Role: Subinvestigator

4. NAVIGATE - BAYER

• Title: A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors
• Role: Subinvestigator

5. RUBY - Tesaro (PRA)

• Title: A Phase 3, Randomized, Double-blind, Multicenter Study of Dostarlimab (TSR-042) Plus Carboplatin-paclitaxel Versus Placebo Plus Carboplatin-paclitaxel in Patients With Recurrent or Primary Advanced Endometrial Cancer
• Role: Subinvestigator

6. ENGOT-ov43/GOG-3036 - MSD

• Title: Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/KEYLYNK001/ENGOT-ov43/GOG-3036)
• Role: Subinvestigator

7. ASTRA ZENECA

• Title: To Study Clinical Effectiveness and Safety of Olaparib Monotherapy in Metastatic Breast Cancer Patients.
• Role: Subinvestigator

8. ROSY-O - ASTRA ZENECA

• Title: Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Olaparib
• Role: Subinvestigator
•  

INTERNATIONAL PUBLICATIONS

I. Published journal articles indexed by SCI, SSCI, and AHCI

Weekly Paclitaxel in Classic Kaposi Sarcoma

• Authors: Paksoy, N., Khanmammadov, N., Doğan, İ., Ferhatoğlu, F., Ahmed, M. A., Karaman, S., & Aydiner, A.
• Journal: Medicine, 102(5)

Carboplatin Desensitization in Ovarian Carcinoma

• Authors: Paksoy, N., Khanmammadov, N., Doğan, İ., Ferhatoğlu, F., Yildiz, A., Ak, N., & Aydiner, A.
• Journal: Medicine, 101(45), e31726

High-Dose Chemotherapy for Ewing’s Sarcoma

• Authors: Paksoy, N., Ferhatoglu, F., Dogan, İ., Khanmammadov, N., Celik, A. I., Gulbas, Z., & Başaran, M.
• Journal: Medicine, 101(49), e32213

Multidrug Refractory TFE3(+) Renal Cell Carcinoma

• Authors: Paksoy, Nail, et al.
• Journal: Journal of Oncology Pharmacy Practice, 2022, 28.1: 215-221

Crizotinib Efficacy in NSCLC with MET Alterations

• Authors: Gürbüz, M., Kiliçkap, S., Bilici, A., Karadurmuş, N., Sezer, A., Şendur, M. A. N., ... & Demirkazik, A.
• Journal: Medicine, 101(50), e32368

Clinicopathological Features in ALK Mutant NSCLC

• Authors: Dogan, I., Gurbuz, M., Paksoy, N., Ferhatoglu, F., Vatansever, S., Saip, P., ... & Aydiner, A.
• Journal: Medicine, 101(34)

PSMA-Based Tumor Burden in Prostate Cancer

• Authors: HAS SIMSEK, Duygu, et al.
• Journal: Annals of Nuclear Medicine, 2021, 35.6: 680-690

Atezolizumab in Metastatic Urothelial Carcinoma

• Authors: TURAL, Deniz, et al.
• Journal: European Urology Focus, 2021, 7.5: 1061-1066

Pulmonary Sarcomatoid Carcinoma

• Authors: FERHATOGLU, Ferhat, et al.
• Journal: Oncology Research and Treatment, 2021, 44.11: 590-601

Prognostic Factors in Atezolizumab-Treated Urothelial Carcinoma

• Authors: TURAL, Deniz, et al.
• Journal: International Journal of Clinical Oncology, 2021, 26.8: 1506-1513

Atezolizumab with Chemotherapy in Small Cell Lung Cancer

• Authors: GÜRBÜZ, Mustafa, et al.
• Journal: Journal of Cancer Research and Clinical Oncology, 2022, 1-9

FOLFIRINOX vs. Gemcitabine + Nab-Paclitaxel in Pancreatic Cancer

• Authors: AY, Seval, et al.
• Journal: Journal of Chemotherapy, 2022, 1-7

Trastuzumab Emtansine in Older HER2-Positive Breast Cancer Patients

• Authors: CIL, Ibrahim, et al.
• Journal: Tumori Journal, 2022, 108.1: 19-25

Real-Life Efficacy of Osimertinib in Advanced NSCLC

• Authors: HIZAL, Mutlu, et al.
• Journal: Journal of Cancer Research and Clinical Oncology, 2022, 148.6: 1501-1508

ALK-Positive Cells Percentage and Alectinib Efficacy

• Authors: Hizal, M., Bilgin, B., Paksoy, N., Atcı, M. M., Kahraman, S., Kılıçkap, S., ... & Şendur, M. A. N.
• Journal: Journal of Cancer Research and Clinical Oncology, 149(8), 4141-4148

Real-World Data on Alectinib in ALK-Positive NSCLC

• Authors: Hizal, M., Bilgin, B., Paksoy, N., Kılıçkap, S., Atcı, M. M., Kahraman, S., ... & Şendur, M. A. N.
• Journal: Future Oncology, 18(23), 2573-2582

Prognostic Factors in Metastatic RCC with T790M Mutation

• Authors: Dogan, I., Iribas, A., Paksoy, N., Vatansever, S., & Basaran, M.
• Journal: Journal of Cancer Research and Therapeutics

FLOT Regimen in Metastatic Gastric Cancer

• Authors: Tastekin, D., Paksoy, N., Dogan, I., Ferhatoglu, F., Khanmammadov, N., Bozbey, H. U., & Karabulut, S.
• Journal: Journal of Cancer Research and Therapeutics

Desensitization Protocol in Lenalidomide Hypersensitivity Reactions

• Authors: DEMIR, Semra, et al.
• Journal: Annals of Allergy, Asthma & Immunology, 2019, 123.4: 394-397

Factors Associated with Diagnostic Skin Test Positivity in PPI Hypersensitivity

• Authors: ÖZDEMIR, Seçil Kepil, et al.
• Journal: Allergy, 2019, 74.6: 1187-1190

Efficacy of Capecitabine and Temozolomide in Neuroendocrine Tumors

• Authors: Ünal, Ç., Azizy, A., Karabulut, S., Taştekin, D., Akyıldız, A., Yaşar, S., ... & Sağlam, S.
• Journal: The Oncologist, oyad257

Subsequent Treatments in Hormone-Positive Breast Cancer Progression

• Authors: Karacin, C., Oksuzoglu, B., Demirci, A., Keskinkılıç, M., Baytemür, N. K., Yılmaz, F., ... & Hacıbekiroğlu, İ.
• Journal: BMC cancer, 23(1), 192

Termination of Trastuzumab in HER2-Positive Metastatic Breast Cancer

• Authors: Dogan, I., Aydin, E., Khanmammadov, N., Paksoy, N., Saip, P., & Aydiner, A.
• Journal: Scientific Reports, 13(1), 8779

Long-term Outcomes and Predictors of Recurrence in Node-Negative Early Stage Breast Cancer

• Authors: Dogan, I., Aydin, E., Khanmammadov, N., Paksoy, N., Ferhatoğlu, F., Ak, N., ... & Aydiner, A.
• Journal: Journal of Cancer Research and Clinical Oncology, 1-9

Prognostic Factors Influencing PFS in HER2-Positive Metastatic Breast Cancer

• Authors: Doğan, İ., Paksoy, N., Ak, N., Vatansever, S., Saip, P., & Aydıner, A.
• Journal: European Journal of Breast Health, 19(2), 128

Treatment Efficacy of Ribociclib or Palbociclib plus Letrozole in Metastatic Breast Cancer

• Authors: Kahraman, S., Erul, E., Seyyar, M., Gumusay, O., Bayram, E., Demirel, B. C., ... & Nahit Sendur, M. A.
• Journal: Future Oncology, 19(10), 727-736

Efficacy and Safety of Sorafenib in Adult Metastatic Osteosarcoma Patients

• Authors: Dogan, I., Paksoy, N., & Basaran, M.
• Journal: Journal of Cancer Research and Therapeutics

Single-Agent Temozolomide as Salvage Therapy in Heavily Pretreated Metastatic Sarcoma Patients

• Authors: Dogan, I., Paksoy, N., & Basaran, M.
• Journal: Journal of Cancer Research and Therapeutics

Outcomes and Prognostic Factors in Metastatic Renal Cell Carcinoma with Brain Metastases

• Authors: Dogan, I., Iribas, A., Paksoy, N., Vatansever, S., & Basaran, M.
• Journal: Journal of Cancer Research and Therapeutics

FLOT Regimen in First-Line Treatment of Metastatic Gastric Cancer

• Authors: Tastekin, D., Paksoy, N., Dogan, I., Ferhatoglu, F., Khanmammadov, N., Bozbey, H. U., & Karabulut, S.
• Journal: Journal of Cancer Research and Therapeutics

Prognostic Factors of Perioperative FLOT Regimen in Operable Gastric Cancer

• Authors: Erol, C., Sakin, A., Basoglu, T., Ozden, E., Cabuk, D., Dogan, M., ... & Sendur, M. A. N.
• Journal: [Not specified]

Efficacy and Outcomes of Systemic Chemotherapy in Posttransplant Kaposi Sarcoma

• Authors: Khanmammadov, N., Paksoy, N., Doğan, I., Ferhatoğlu, F., Saip, P., & Aydiner, A.
• Journal: Medicine, 102(39), e35383

Comparison of Second-Line Treatments in Metastatic Renal Cell Carcinoma

• Authors: Pehlivan, M., Paksoy, N., Aydin, E., Basaran, M., & Ekenel, M.
• Journal: Medicine, 102(41), e35245

Toxicity Management and Effectiveness of Regorafenib in Advance GIST Patients: A Real-world Study - Authors: Paksoy, N., Ferhatoğlu, F., Doğan, İ., Khanmammadov, N., Bozbey, H. U., Karabulut, S., & Taştekin, D. - Journal: TURKISH JOURNAL OF ONCOLOGY, 1(1)

Demographic and Clinical Features and Factors Associated with Survival in Patients with Primary Glomerulonephritis: Single Tertiary Center Experience - Authors: Paksoy, N., Trabulus, S., Seyahi, N., & Altiparmak, M. R. - Journal: Namik Kemal Tip Dergisi, 11(1)

Efficacy of Sorafenib in Symptomatic Patients with Pretreated Progressive Desmoid Tumors - Authors: Paksoy, N., Ferhatoglu, F., Dogan, I., Ak, N., Pehlivan, M., Ekenel, M., & Basaran, M.

Nodal Response to Neoadjuvant Chemotherapy is a Better Predictive Factor of Survival Than Miller-Payne Scoring in Breast Cancer - Authors: Ak, Naziye, et al. - Journal: Journal of Oncological Sciences, 7.2: 42-49

Evaluation of Prognostic and Predictive Values of Hemogram Parameters in Patients with Advanced Stage Ovarian Carcinoma - Authors: Ak, Naziye, et al. - Journal: Turkish Journal of Oncology/Türk Onkoloji Dergisi, 2021, 36.4

Identifying Risk Factors Associated with Survival and Drug-Related Toxicities in Imatinib-Resistant Gastrointestinal Stromal Tumor (GIST) Patients Treated with Sunitinib - Authors: Ferhatoglu, F., Karabulut, S., Paksoy, N., & Tastekin, D.

Real-life Outcomes of ROS1 Fusion-positive Metastatic Lung Cancer Patients who were Treated with Crizotinib - Authors: Dogan, İ., Khanmammadov, N., Paksoy, N., Ferhatoglu, F., Aydın, E., Vatansever, S., & Aydine, A. - Journal: TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY

Predictors of the acquisition of T790M mutation in EGFR-mutant metastatic lung cancer patients who were treated with EGFR inhibitors - Authors: Dogan, I., Khanmammadov, N., Paksoy, N., Vatansever, S., Saip, P., & Aydıner, A. - Journal: Eurasian Journal of Pulmonology

Laterality of Adrenal Gland Metastasis in Lung Cancer: Results of a Comparative Study - Authors: Ferhatoglu, F., Gagatay, T., Okumus, G., Aydiner, A., Paksoy, N., Ak, N., ... & Saip, P. - Journal: Eurasian Journal of Medical Investigation, 7(2)

Poor Risk Factors Affecting Cancer Patients Infected with Covid-19: A Retrospective Comparative Study from a Pandemic Hospital - Authors: Ferhatoglu, F., Kapağan, T., Paksoy, N., Ak, N., Medetalibeyoğlu, A., Şenkal, N., ... & Vatansever, S. - Journal: Turk Onkoloji Dergisi, 38(1)

Systemic Treatment Outcomes of Progressive Medullary Thyroid Carcinoma from the Registries of a Tertiary Cancer Center - Authors: Ferhatoglu, F., Paksoy, N., & Başaran, M. - Journal: Namik Kemal Tip Dergisi, 10(4)

Evaluation of clinical features and risk factors related to late recurrence (> 5 years) in patients with breast cancer - Authors: Ferhatoglu, F., Aydiner, A., & Paksoy, N. - Journal: Journal of Surgery & Medicine (JOSAM), 6(12)

Assessing the Clinical Impact of Lutetium-177 DOTATATE Peptide Receptor Radionuclide Therapy (PRRT) on Metastatic Neuroendocrine Tumors: A Multicenter Real-World Data from Türkiye

Thesis:

Istanbul University Cerrahpaşa Medical Faculty, Internal Medicine Department PAKSOY, Nail. Demographical, clinical characteristics and survival factors in patients withprimary glomerulonephritis: Cerrahpasa Medical Faculty Experience. (2016)

International Refereed Congress / Symposium Publications in Proceedings (ASCO/ESMO Abstracts)

Prognostic factors influencing progression-free survival in HER2 positive metastatic breast cancer patients who treated with lapatinib and capecitabine combination

• Authors: Dogan, I., Paksoy, N., Ak, N., Vatansever, S., Saip, P., & Aydiner, A. (2022)

Efficacy of regorafenib and 5-fluorouracil-based rechallenge treatment in the third-line treatment of metastatic colorectal cancer: A Turkish oncology group study

• Authors: Şenocak Taşçi, E., Oyan, B., Sonmez, O., Mutlu, A. U., Atcı, M. M., Oner, I., ... & Gulmez, A. (2022)

Long-term outcomes and predictors of recurrence in patients with early-stage node-negative breast cancer

• Authors: Dogan, I., Aydin, E., Paksoy, N., Ferhatoglu, F., Ak, N., Ibis, K., ... & Aydiner, A. (2021)

Efficacy of temozolomide in pretreated patients with metastatic sarcoma

• Authors: Paksoy, N., Dogan, I., Ekenel, M., & Basaran, M. (2021)

Efficacy of sorafenib in symptomatic patients with pretreated progressive desmoid tumors

• Authors: Ferhatoglu, F., Paksoy, N., Dogan, I., Ak, N., Pehlivan, M., Ekenel, M., & Basaran, M. (2021)

Efficacy of sorafenib in heavily pretreated adult patients with metastatic osteosarcoma

• Authors: Paksoy, N., Dogan, I., Ekenel, M., & Basaran, M. (2021)

Outcomes and prognostic factors in metastatic renal cell carcinoma patients with brain metastases

• Authors: Dogan, İ., Iribas, A., Paksoy, N., Ekenel, M., Vatansever, S., & Basaran, M. (2021)

Association of response to first-line chemotherapy with the efficacy of atezolizumab in patients with metastatic urothelial carcinoma

• Authors: Tural, D., Olmez, O. F., Sümbül, A. T., Artac, M., Ozhan, N., Akar, E., ... & Erman, M. (2021)

Safety and survival in adult women with platinum-sensitive relapsed BRCA mutant ovarian cancer: A study of patients in Olaparib Turkey Early Access Program—LynTurk study

• Authors: Esin, E., Ahmed, M. A., Yıldırım, H. Ç., Mandel, N. M., Erdemoglu, E., Sari, M., ... & Paydas, S. (2023)

Atezolizumab in patients with metastatic urothelial carcinoma who have progressed after first-line chemotherapy: Results of real-life experiences

• Authors: Tural, D., Ölmez, Ö. F., Sümbül, A. T., Artaç, M., Özhan, N., Akar, E., ... & Kılıçkap, S. (2021)

Trustworthy, attentive, successful neurosurgeon with over 34 years of experience, high rate of success and exceptional surgical skills, providing quality neurological service for patients, successfully treating over thousands of patients suffering from many severe, complex conditions of the brain, spine and the nerves. 

Experienced in performing treatment modalities like micro neurosurgery, endoscopic skull base surgery, endoscopic third ventriculostomy, minimally invasive spine surgery and percutaneous spine surgery. Keen on performing clinical research and attending national and international medical conferences to stay abreast of new technologies in the field. Compassionate and detail-oriented with excellent communication skills. Expertise in healthcare, education and program management. Adept at developing and implementing forward-thinking strategies to enhance patient outcomes and collective knowledge in the field. Desiring to bring skills and success. Focused on working closely with other medical professionals and following up with patients. Well-versed at emergency procedures and fast and accurate sanitation.

Work History

2020-01 – Current - Asst. Prof. Neurosurgeon

Istanbul Medipol University, Health Care Practice and Research Center Pendik Hospital

• He successfully treated and followed patients with cerebral hemorrhage, brain and spinal cord tumors, and patients with hydrocephalus.

• He performed transnasal pituitary surgeries with success.

• Also, many cervical lumbar and thoracic disc patients were successfully treated, and disc prosthesis were applied to some of them.

• He re-operated a degenerative spine patient who had been operated on before at another center and the patient regained his health.

• He also successfully treated patients with premature neonatal intracerebral hemorrhage.

2019-08 – 2020-01 - Neurosurgeon

Freelancer, Istanbul, Turkey

• Operated on patients' brains, spines and peripheral nerves to correct deformities, repair injuries, prevent and treat diseases and improve patients' motor functions. Performed successful operations for complex, advanced and complicated disease of the brain and spine some of which were operated unsuccessfully at other medical centers by different neurosurgeons.

• Offered advanced knowledge, leadership abilities and technical assistance with complex surgical cases.

• Maintained admitting privileges at local hospitals and provided quality follow-up care.

• Educated patients on recovery methods and times.

• Designed treatment plans for patients.

• Thoroughly assessed patients to identify medical condition and level of surgical risk.

• Founded a spinal surgery group with orthopedic surgeons and treated very advanced and severe vertebra deformities, spine abnormalities, scoliosis.

2018-12 - 2019-08 - Neurosurgeon

Alkafeel Super Speciality Hospital, Karbala, Iraq

• Conducted up to 5 operations per month to correct deformities in neurological and spinal systems, repair traumas, and treat diseases of different areas. Performed successful operations (success rate 100 percent : 90-95) for severe, complex and advanced diseases of the brain, spine and nerves in adults and children. (Cerebral intrinsic and extrinsic tumor surgery, posterior fossa surgery, spontaneous and traumatic intracranial hematomas, Interhemispheric 3th ventricle and lateral ventricle surgery, pontocerebellar angle tumor surgery, spinal instrumentation and fusion surgery, microdiscectomy cervical, thoracic, lumbar, pediatric cranial and spine anomaly surgery). Followed the patients postoperatively.

• Educated patients on recovery methods and times.

• Thoroughly assessed patients to identify medical condition and level of surgical risk.

• Performed emergency surgeries.

• Examined 900 patients in total in the outpatient clinic and gave medical treatments to them when necessary.

2015-10 - 2018-11 - Neurosurgeon

Medistate Kavacık Hospital, Istanbul, Turkey

• Operated on patients' brains, spines and peripheral nerves to correct deformities, repair injuries, prevent and treat different advanced, complex severe diseases and improve patients' motor functions.

• Conducted up to operations per month to correct deformities in neurological and spinal systems, repair traumas, restore partial or full functionality and prevent and treat diseases of different areas. 

• Performed successful operations (success rate percent : 95) for severe, complex and advanced diseases of the brain , spine and nerves in adults and children.(Brain tumor, arachnoid cyst, intracerebral hematoma, spinal stenosis, hydrocephalus, myelomeningocele).Followed the patients postoperatively. 

• Educated patients on recovery methods and times Thoroughly assessed patients to identify medical condition and level of surgical risk.

• Performed emergency surgeries (intracerebral hematoma, intracerebral abscess).

• Examined 850 patients in total in the outpatient clinic and gave medical treatment to them when necessary.

1994-03 - 2015-09 - Neurosurgeon

Ankara Training and Research Hospital, Ankara, Turkey

• Supervised trainees, medical students, residents and fellows to help each achieve proficiency in field.

• Conducted up to 20 operations per month to correct deformities in neurological and spinal systems, repair traumas, restore partial or full functionality and prevent and treat diseases of different areas. Performed successful operations (success rate: %90) for severe, complex and advanced diseases of the brain, spine and nerves in adults and children. (Skull base surgery, extended trans base approach, orbit zygomatic approach, presigmoid approach, orbital approaches, transcranial and lateral orbitotomy, Endoscopic transsphenoidal pituitary surgery, CSF leakage surgery, endoscopic, microscopic and transsphenoidal, transcranial. Endoscopic third ventriculostomy and surgery of multiloculated hydrocephalus and pediatric neurosurgery. Cerebral intrinsic and extrinsic tumor surgery, posterior fossa surgery. Brain aneurysm, AVM and cavernoma surgery.

• Spontaneous and traumatic intracranial hematomas. Hemifacial spasm and trigeminal neuralgia surgery (microsurgical decompression) Interhemispheric 3th ventricle and lateral ventricle surgery. Pineal area surgery. Pontocerebellar angle tumor surgery.

• Foreman magnum tumors surgery. Surgery of hydrocephaly, Syringomyelia and craniovertebral animalia).Followed the patients postoperatively.

• Educated patients on recovery methods and times Thoroughly assessed patients to identify medical condition and level of surgical risk.

• Performed emergency surgeries (Epidural, subdural and intracerebral hematoma, vertebra fracture).

• Examined 500-700 patients per day in the outpatient clinic and gave medical treatment to them when necessary. Examined patients in the emergency service.

• Designed treatment plans for patients.

• Offered advanced knowledge, leadership abilities and technical assistance with complex surgical cases.

• Led and oversaw 15 medical personnel in operating room setting to perform surgeries.

• Led and oversaw medical personnel in operating room setting to perform surgeries.

Education

1982-09 - 1988-08

M.D.: Medicine And (Pre-Medicine)

Ankara University Medical School - Ankara

General Medicine Training for 6 years. Graduated with a high GPA.

1988-11 - 1994-05

Specialist Neurosurgery: Neuroscience

University of Health Sciences - Ankara

6 years of neurosurgery training.

• My thesis was on brain abscess and their clinical and laboratory evaluations

1995-05 - 1995-07

Neuroscience

The Institute of Neurological Sciences and Psychiatry.

Ankara

I attended the course for microsurgery at University of Hacettepe Institute of Neurological Sciences and Psychiatry.

1998-04 - 2019-05

Observer Doctor: Neuroscience

Department of Neurosurgery, MSU - Ann Arbour, 

Michigan USA

2012-05 - 2012-05

Neuro endoscopy: Neuroscience

Ghent University - Ghent, Belgium

International endoscopic neurosurgery workshop, 

Ghent, Belgium

I attended the workshop for endoscopic skull base operations the and Neuro endoscopic third ventriculostomy at University of Ghent Hospital

Skills

Micro neurosurgery - Excellent

Neuro endoscopy - Excellent

Cranial base endoscopy - Excellent

Minimal invasive surgery - Excellent

Percutaneous spinal surgery - Excellent

Neuronavigation – Excellent

Certifications

1995-04 Microsurgery

2012-05 Endoscopy

Languages

Turkish - Native

English - Advanced

Arabic - Novice

Affiliations

Turkish Neurosurgical Society

Turkish Medical Association

Accomplishments

• Trained team of staff nurses in medical office procedures to ensure consistent quality of care.

• Published 17 articles in national and international reviews and presented papers in medical congresses.

Interests and operations I perform

Vascular diseases of brain

Endoscopic hypophysis surgery

Tumors of brain, spine and medulla spinalis surgery

Endoscopic brain ventricle surgery

Endoscopic third ventriculostomy 

Traumas of brain and spine

Cervical, thoracic and lumbar disc hernias and narrow 

canal disease surgery

Spine instrumentation and fusion surgery

Baclofen pump and neurostimulators insertions

Hydrocephalus surgery

Congenital diseases of the brain and spine (pediatric 

neurosurgery)

Peripheral nerve surgery

Education

2019

Istanbul Faculty of Medicine, Electroneurophysiology

2005

Istanbul University Cerrahpasa Faculty of Medicine, Neurology

1998

Istanbul University Cerrahpasa, Faculty of Medicine

Experience

2017 - 2019

Private Adatip Kurtkoy Hospital

2016

TND – Schering-Plough Proceedings of the Year Awards

2015 - 2017

Istanbul Yeni Yüzyıl University Private Gaziosmanpaşa Hospital

2015 - 2015

Şişli Hamidiye Etfal Training and Research Hospital

2005 - 2014

Private Avicenna Hope Hospital

2015 – 2019 Istanbul University Cerrahpasa Faculty of Medicine

2019 – Medipol University Pendik Hospital

Publications

1- Yüz Ağrılarında Trigeminal SEP Uygulaması ; Yüksek Lisans Tezi

2- Glial Tümörlerde P53 , PTEN ve EGRF Pozitifliğinin İmmunohistokimyasal ; Uzmanlık Tezi

3- Two siblings with homocystinuria presenting with dystonia and parkinsonism

4- Lack of association between IL-1ß/? gene polymorphisms and temporal lobe epilepsy with hippocampal sclerosis

5- Psychogenic movement disorders in two children

6- Temporal Lob Epilepsi ve Hippokampal Sklerozlu Hastalarda İnterlökin 1-ß ve İnterlökin 1-? Gen Polimorfizminin Analizi

7- Hippokampal Skleroza Bağlı Mesial Temporal Lob Epilepsisi İle İnterlökin 1-ß ve İnterlökin 1-? Gen Polimorfizmi İlişkisinin Araştırılması

Prof. Dr. Mustafa ÖZATEŞ

Dr Ozates was born in 1966 in Birecik district of Sanliurfa in Turkey. He completed his primary and secondary education in my hometown, Birecik. He got into Istanbul University Istanbul Faculty of Medicine in 1983. After 6 years of successful education, he started Radiology education at Dicle University Faculty of Medicine by passing the Medical Specialization Examination (TUS) in the same year I graduated in 1989.

Between 1993 and 1995, he worked as a Radiology Specialist in various hospitals in Gaziantep. He passed the Assistant Professorship exam and started to work as a faculty member at Dicle University in 1995.

Post-Specialization Trainings:

2003, Gazi University Faculty of Medicine, MRI Department, Ankara

2003, Marmara University Faculty of Medicine, MRI Department, Istanbul

2001-2004, ESNR European Course of Neuroradiology (3 Semesters)

1997, Johns Hopkins University, Neuroradiology, Baltimore, USA

1997, Cornell University, Neuroradiology, New York, USA

1996, Istanbul University Faculty of Medicine, MRI Department, Istanbul

1994, Dokuz Eylül University Faculty of Medicine, MRI Department, İzmir

1993, Uludağ University Faculty of Medicine, MRI Department, Bursa

1993, UCLA Medical Center (as visitor), Los Angles, USA

1992-1993, Maçka EMAR, Dr. Murat Dinçer, Istanbul

His Academic Studies:

International Publications: 23

International Papers: 27

National Publications: 45

National Papers: 48

Conferences: 11

Citations: 210 Scientific Publications (Average Citations per Item: 10.50, h-index: 9), USA edition 1 Book, Various Conferences

Scientific Organizations he is a member of:

European Society of Radiology (ESR)

Turkish Radiology Association (TRD)

Magnetic Resonance Association

Istanbul Medical Chamber (ITO)

Turkish Neuroradiology Association

In 2003, he was awarded the title of Associate Professor with the examination held at Marmara University Faculty of Medicine. In 2005-2013, Dr. Lütfi Kırdar Kartal Training and Research Hospital Radiology Clinic Chief, Training and Administrative Officer.

In 2013, he started to work as a professor at Nişantaşı University. On March 15, 2013, he was appointed as the Inter-University Board Representative for 1 year. He is a Member of the Board of Trustees of Ayvansaray University. He is a sub – specialist in “Pediatric Radiology”

His articles have been published in many magazines in Turkey and abroad. He presented written and oral presentations and gave conferences at congresses in various cities and countries.

As the Radiology Clinic Chief of Bağcılar Training and Research Hospital, he is the first professor who performed Coronary CT Angiography in a state hospital in Istanbul.

He is one of Turkey’s first Children’s Radiology Specialist Minor. He did his military service between March and April 2000 at the 200-bed Malatya Military Hospital.