Лікування в Мілане (Італія)

Prof. Eduardo Nobile Orazio is the Neurology Unit Director in Humanitas Research Hospital. 

His main areas of interest and specialisation are: diagnosis and treatment of neuromuscular diseases, in particular polyneuropathies, also including those of immunological origin such as Guillain Barré Syndrome (GBS) and the different clinical variants, chronic inflammatory demyelinating polyneuropathy (CIDP), multifocal motor neuropathy (MMN), and the polyneuropathies associated with monoclonal gammopathy, the neuropathies and paraneoplastic neuronopathies and neuropathies in the course of haematologic diseases and from chemotherapy. 

Immunological diagnosis of autoimmune diseases of the peripheral and central nervous system, diagnosis and treatment of motor neurone disease with suspected paraneoplastic or immune genesis, diagnosis and treatment of Multiple Sclerosis and other autoimmune and inflammatory diseases of the central nervous system such as autoimmune and paraneoplastic encephalitis, diagnosis and treatment of Parkinson’s Disease and extrapyramidal diseases.

His areas of research are clinical and immunological diagnosis and treatment of the immune mediated polyneuropathies and, in particular, GBS, CIDP, MMN and polyneuropathy associated with monoclonal gammopathy including POEMS.

Prof. Eduardo Nobile Orazio has written over 230 scientific publications, held more than 85 university seminars or conferences. He has been a member of the SIN since 1991, of the European Neurological Society since 1989 until 2014, when he joined the European Academy of Neurology. Prof. Eduardo Nobile Orazio has also been a member of the American Academy of Neurology since 1998 and of the American Neurological Association since 2012.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=Nobile-Or  

Dr. Nunzio Paolo Nuzzi has graduated at Università Cattolica del Sacro Cuore (Milan) and carried out his specialisation in neuroradiology. He is the Unit director of Interventional radiology at Humanitas Research Hospital.

Medical areas of interest: interventional neuroradiology, cerebrovascular diseases, ischemic and haemorrhagic stroke, brain aneurysms, brain and spinal arteriovenous malformations and arterial-venous fistulas (AVF), intracranial stenosis and neck stenosis.

Research areas of interest: new biomedical devices for the treatment of cerebrovascular diseases. Clinical research on minimally invasive endovascular procedures.

Dr. Paola Maria Magnoni has graduated in general medicine and radiodiagnostics at Università degli Studi of Milan and is the Ultrasound Unit Director of Humanitas Research Hospital, where she dedicates especial attention to internal, oncological, breast, endocrinology and loop ultrasound, performing over 5000 examinations of which 500 needle biopsy annually.

Medical areas of interest: Ultrasound in all its fields of use, especially:

Diagnostic ultrasound: internal, oncological, intestinal loops, endocrinology.

Interventional ultrasound: superficial needle biopsies of areas such as breast, thyroid, soft parts; and deep needle biopsies of areas such as abdominal organs, liver, kidney pancreas; retroperitoneum; paracentesis, thoracentesis, drainage and inflections.

Research areas of interest: sarcomas, early diagnosis in oncological pathologies, iconographic study of IBD, senology, endocrinology.

Born in 1955, Prof. Paolo Emanuele Levi Setti graduated in Medicine and Surgery at the University of Milan School of Medicine in 1982 and specialized in Obstetrics and Gynaecology at the same University in 1988.

At the beginning of his career he was involved in the early developments of ultrasound imaging in obstetrics and gynaecology and more recently in the new applications of transvaginal and colour flow technology. From 1977 to 1982 microsurgery and endoscopy were his main interest in the investigation and treatment of female infertility.

Surgical applications in the animal model of new approaches to pelvic pathology were the first studies he published in literature. From 1985 to 1989 fetal blood sampling and prenatal diagnosis had a main role in his interest in research development. In this period, he participated in many published studies in this research area and one of the greatest experiences in the world was reported in the field of echographic surgery.

Results of in vitro fertilization, implantation, intrauterine embryo transfer, assisted reproduction in sexually transmitted diseases, evaluation of the uterine cavity in infertile patients and cryopreservation, are the main aspects of his present day scientific interest. In 1984, together with a group of colleagues, he founded one of the first centres in Italy operating in assisted reproduction. From 1988 to 1996 Prof. Levi Setti chaired the Infertility and Assisted Reproduction Unit of the Department of Obstetrics and Gynaecology – S. Paolo Biomedical Institute – University of Milan School of Italy operating in assisted reproduction. 

From 1989 to 1996 he coordinated the first European centre for assisted reproduction for HIV serodiscordant couples. Since 1994 he is a visiting lecturer at the 1st postgraduate School in Obstetrics and Gynecology and he is a visiting lecturer in the graduate course of Obstetrics and Gynaecology – University of Milan, School of Medicine.
Involved since the earliest development of endoscopy in gynaecology, he followed the evolution of this surgical approach performing, in over 25 years of activity, more than 15.000 procedures and mentoring an impressive number of fellows in this area. His Department has run for many years one of the largest ART programs in our country and in Europe. His research interest has, over the last few years, focused on the mechanisms of implantation, on the preservation of female and male fertility and on the complications and outcome of assisted reproduction. His Department performed the probably larger number of oocyte’s freezing procedures in infertile patients in Europe and is now a recognised expert in fertility preservation in oncological and fertility deferring patients. He has been the scientific organizer of several international meetings and training courses in Reproductive Medicine. 

Member of many international institutions in the field of reproductive medicine (American Society for Reproductive Medicine, European Society of Human Reproduction and Embryology, International Society for Fertility Preservation), he was elected President of the Italian Fertility and Sterility Society (SIFES e MR) onto the board in 1999 and in 2003 and for two mandates (2009-2001 and 2011-2013). 

He is the author of more than 100 published articles, reviews and chapters in books. 

From 2004 Prof. Levi Setti collaborates with the Italian Ministry of Health in revising data of the National Medically Assisted Reproduction Register. In December 2010 he was nominated scientific coordinator of an experimental project for an ART Network in Lombardy County. Since 1996 Prof. Levi Setti works at the Humanitas Research Hospital in Milan and is currently chair of the Department of Gynaecology and heads the Division of Gynaecology and Reproductive Medicine. In May 2011 he was appointed, for the period July 2011- June 2016, as Adjunct Professor at Yale University, School of Medicine. In June 2013 he supervised and is actually personally directing the Humanitas Fertility Center, where over 3.500 ART procures are performed annually.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=levi sett

Prof. Dr. Maria Grazia Bordoni is the Vascular Surgery Unit Director in Humanitas Research Hospital. She has graduated at Università degli Studi of Milan and specialised as a vascular surgeon and since then she has been interested in vascular surgery in all its aspects.

Medical areas of interest:

Her main specialties are endovascular surgery and treatment of the large vessels of the abdomen and thorax (aorta, thoracic cavity), carotid surgery, endovascular and surgical treatments for arteries of the lower limbs, preparation of complex vascular access in hemodialysis, phlebology, diagnosis and treatment of vascular malformations. 

Research areas of interest: 

When it comes to the research activity, Dr. Bordoni is mainly dealing with early treatment of acute ischemic strokes and stimulation of the carotid baroreceptors in patients with heart failure. Prof. Bordoni has performed more than 2000 surgeries as first surgeon in her Humanitas career. 

Since 2005, she is also Milan University professor: she teaches General Surgery and focuses on the topic of vascular and surgical emergencies.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=bordoni+mg

Prof. Alessandro Repici is the Director of the Gastroenterology and Digestive endoscopy Unit in Humanitas Research Hospital. Graduated in Medicine and Surgery in 1990 and the following year he won a scholarship at the Department of Gastroenterology Molinette hospital in Turin, where he began his practice in digestive endoscopy. In 1992, he worked with Prof. Claude Liguory as a fellow at the American Hospital in Paris.

In 1994 he became a specialist in Gastroenterology and Digestive Endoscopy at the University of Messina and worked in the Department of Gastroenterology, Ospedale Maggiore Molinette of Turin.

In the following years, he has been working at the Service of Digestive Endoscopy of Altona Hospital in Hamburg, directed by prof. Hagenmuller, and in the Department of Gastroenterology Molinette Hospital in Turin, directed by prof. Rizzetto. In 1999, he was a Research Fellow at the Center for Oncological and Operative Endoscopy of Wellsley Hospital in Toronto.

He teaches Gastroenterology and Digestive Endoscopy at the School of Specialization in Oncology since 2000, at the University of Turin since 2004 and Endoscopy Diagnostic Techniques and Operations at the School of Specialization in General Surgery I and II of the University of Turin.

The clinical activity and research of Prof. Repici mainly focuses on the development of new endoscopic techniques in the field of diagnosis and therapy, with particular attention to new methods of endoscopic removal of cancerous lesions and early in the palliation of advanced gastrointestinal malignancies.

Prof. Repici is coordinator, principal investigator and co-investigator in more than 50 studies, including phase II and III for FDA and EMA approval of new molecules and new instruments for diagnostic and operational endoscopy. 

Prof. Repici collaborates on research projects in the field of endoscopy with the University of Rotterdam, in Haifa, in New York and with several Italian centers. He is a member of various national and international scientific society of Gastroenterology and Digestive Endoscopy.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=repici+alessandro

Prof. Andrea Lania has graduated at the Università degli Studi of Milan and is specialized in endocrinology. He is the Unit Director of Endocrinology and Diabetology in Humanitas Research Hospital and his specialization is pituitary diseases, pituitary adenomas, thyroid cancer, pancreatic neuroendocrine tumors, poorly differentiated neuroendocrine carcinomas.

Medical areas of interest:
Pituitary tumors, hypopituitarism, acromegaly, Cushing’s disease and syndrome, neuroendocrine tumors, thyroid and thyroid diseases, adrenal and adrenal diseases, hypogonadism.

Research areas of interest:
Study of the pathogenetic mechanisms of pituitary and neuroendocrine tumors, of the molecular mechanisms responsible for the different response of pituitary and neuroendocrine tumors to medical therapy.

Prof. Lania published 198 peer-reviewed papers (Google Scholar H-Index 47; Scopus H-Index 38, cit tot 4604)

Prof. Lania has a long standing expertise in the field of intra-cellular signaling in endocrine tumors. In particular, in the past ten years, he contributed to analyze the role of PKA regulatory subunits in the pathogenesis and control of cell proliferation of endocrine tumors. Moreover, he contributed to define the role of SSTR5 domains involved in the intracellular trafficking of this receptor in human pituitary cells and to analyze the impact of DR2R and SSTR2&5 polymorphic variants on both the clinical outcome and response to medical treatment in patients with pituitary tumors.

Recently, he contributed to identify the role of cytoskeleton protein FLNA in mediating both intracellular signaling and membrane targeting of somatostatin type 2 receptor and D2R in pituitary and pancreatic neuroendocrine tumors. Finally, he contributed to explore the intracellular mechanisms possibly involved in mediating the interplay between drugs commonly used in the treatment of neuroendocrine tumors.

Previous experience:
2005-2008 Fondazione Ospedale Maggiore Policlinico IRCCS, Milan, Italy
Director of Endocrinologic Day Hospital and surgery on pituitary disorders. 

Publications: https://www.ncbi.nlm.nih.gov/pubmed?term=lania%20A 

Dr. Corrado Lodigiani has been assistant at the Thrombosis Centre of Humanitas research Hospital from 1998 to 2013 and he became Unit Director in 2013. 

Humanitas Thrombosis Center is a state-of-the-art service for the proper management of the diagnosis and therapy of venous thromboembolic pathology (deep and superficial venous thrombosis, pulmonary thromboembolism, visceral venous thrombosis) and arterial (myocardial infarction, cerebral stroke, peripheral arterial disease). 
Other also rare diseases treated are atypical thrombosis, such as the vascular circulation of the retina, the hearing system and the placental circulation during pregnancy. 

Dr. Lodigiani adopts the multidisciplinary approach and works in collaboration with all medical and surgical specialties. In particular, he carries out clinical and instrumental diagnostics (vascular ecocolordoppler) and research on the causes, diagnosis and therapy of thrombotic and bleeding disorders, congenital and acquired. His clinical activity also involves the diagnosis and management of patients suffering from bleeding diseases, such as haemophilia, von Willebrand’s disease and platelet diseases.

Medical areas of interest:  

In recent years, he has devoted himself with particular interest to the testing, in the role of Principal Investigator in International Clinical Studies, of new antithrombotic drugs and, above all, anticoagulants, which are about to be marketed and will constitute a valid and safe alternative to traditional oral anticoagulant therapy (DOACs). He is also working, with great interest, on researching the causes of idiopathic infertility and the usefulness and effectiveness of some therapeutic strategies, such as the use of anticoagulant drugs, improving the results of artificial insemination procedures. He is the author of numerous articles in international scientific journals and speaker at numerous national and international conferences.

Dr. Daniela Pini is the Head of the Cardio-respiratory rehabilitation Unit.

Medical areas of interest: Dr. Daniela Pini has been working and researching heart failure and has gained considerable experience in the management of advanced forms of this pathology. She is also very interested in the evaluation and "overall" management of patients suffering from this disease, which mainly affects elderly people and who already have other chronic diseases, which, if neglected, can easily impair the effectiveness of treatment for heart failure itself.

Research areas of interest: new therapies for advanced heart failure: replacement therapy of the heart with mechanical assistance devices to the circulation or heart transplant. New drugs and devices. Multidisciplinary patient management programs.

Further information of interest: thanks to the high competence of cardiosurgeons, electrophysiologists and hemodynamists, Humanitas can count, as a clinical cardiologist, on a team that allows it to offer the patient all the range of therapeutic options for heart failure.

From June 2000 to October 2001 she was Visiting Assistant Professor at the Cardiovascular Division Hospital of the University of Pennsylvania. During this period, she worked in the Heart Failure/Heart Transplantation Program, where she participated in the management of patients with advanced heart failure waiting for transplantation, dealing in particular with medical complications in patients with mechanical assistance devices. She has also worked with kidney, kidney-pancreas, pancreas-insulae, lung, liver and heart transplant teams, dealing with the multiple aspects of managing solid organ transplant recipients.

She worked in the Niguarda Ca' Granda Hospital, at the Cardiomyopathy and Heart Transplantation Service, dealing mainly with patients with advanced heart failure and undergoing a cardiac transplant.

Dr. Pini is a member of the coordination committee of the Decompensation Area of the National Association of Medical Hospital Cardiologists – ANMCO. In the last two years she has been mainly concerned on building a network of “heart failure clinics” on the national territory.

Dr. Federico Pessina is the Cranial Neurosurgey Unit Director.

Medical areas of interest: Brain tumors, glioblastomas, low grade gliomas, brain metastases, meningiomas, neuromas, cavernous angiomas, brain aneurysms

Surgical treatment with brain mapping techniques, awake and minimally invasive surgery of all central nervous system tumors.

Surgical treatment of highly complex tumors of the skull base and cranio-cervical hinge: meningiomas, neuromas, craniopharyngiomas, brain stem tumors.

All the tumor pathologies described above are addressed after multidisciplinary multi-specialist evaluation.

The surgical approach is customized to the patient and to the type of lesion, making use of the most advanced intraoperative techniques for malignant brain tumors (neuronavigation, intraoperative neurophysiology, intraoperative CT) and more complex approaches (anterior, posterior and combined petroosectomies, minimally invasive accesses) for benign diseases of the skull base such as meningiomas and neuromas.

Research areas of interest: Experimental protocols in the treatment of glioblastomas

- Prospective protocols in the treatment of brain metastases

- Role of surgical removal and integrated treatments in glioblastomas and malignant brain tumors

- Intracranial meningiomas

- Cadaver lab dissection

Author of more than 60 scientific publications and 5 book chapters, he is member of Italian Society of Neurosurgery (SINCH).

In 2018 he joined the Scientific Committee of European Society of Neuroncology (EANO) and the Skull Base Surgery Committee of World Federation of Neurosurgical Society (WFNS).

Specialized training: 

Prof. Pessina obtained his Degree in Medicine and Surgery in University of  Insubria,  Varese, where he also completed his Residency Program.

From 2007 to 2008 he covered the role of Clinical Fellow in Neurosurgery in Lausanne University Hospital, focusing on image-guided intrinsic brain tumors resection and vascular neurosurgery

In 2018 he covered the Skull Base fellow position in Lariboisiere Hospital, Paris, fully dedicating to skull base surgery and hands-on dissection practice and teaching.

Since 2022, he is Full Professor in Neurosurgery (MED/27) in Humanitas University

Additional information of interest:

Member of the Scientific Committee of the European Association of Neuroncology (EANO)

Publications:  https://www.ncbi.nlm.nih.gov/pubmed/?term=Pessina+Federico

Dr. Giuseppe Marinari is a specialist in general surgery (1991) and nutrition (1995). He started his career in Bariatric Surgery in 1987 and, since then, he has performed over 7000 bariatric procedures, mainly Sleeve Gastrectomy, Gastric Bypass, and Biliopancreatic Diversion. Dr. Giuseppe Marinari has international experience, and he is one of the leading Bariatric surgeons in Italy. Over the past 10 years, he has focused on the implementation of a high-volume centre (>1250 procedures in 2019). Since 2016, he adopted an Enhanced Recovery After Bariatric Surgery (ERABS) protocol, to improve benefits for the patient. In essence, this means a faster recovery and an early return to daily activities, with a very high patient approval rating.

Obesity is a complex condition that encompasses a variety of comorbidities. Therefore, the role of a bariatric surgeon is multidisciplinary, including the understanding (and sometimes treating) of comorbidities as well as performing surgery.

Bariatrics interested Dr. Giuseppe Marinari at first because it was a new and growing field. He then developed an appreciation for the multidisciplinary aspect. Now Dr. Giuseppe Marinari is eager to help people transform their lives.

Dr. Giuseppe Marinari  was mentored by Prof. N. Scopinaro at the University Hospital in Genoa, Italy. He invented the biliopancreatic diversion (with or without duodenal switch), a malabsorptive bariatric operation. Dr. Marinari is now Director of the Bariatric Center. He has international experience and is one of the leading surgeons in his field. He performs both restrictive and malabsorbative bariatric procedures, mainly using the laparoscopic approach. In Humanitas Reasearch Hospital patients are treated by a multi-disciplinary team. The patients are given full attention and support throughout all the steps along the treatment.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=marinari+giuseppe

Dr. Paolo Omodei is the Unit Director of the Autonomous section of Clinical Gastroenterology.

He graduated with honors in the academic year 1988-89 at the Università degli studi of Milan. He specialized in Gastroenterology and Digestive Endoscopy in 1994. Winner of the competition for PhD in Research in Clinical Methodology in the academic year 1994-95. In 1996 he won the public competition for Assistant at the Gastroenterology Service of the Niguarda Ca' Granda Hospital in Milan. He held this post until June 1997. From 1997 to 1999 he held the position of Assistant at the Gastroenterology and Digestive Endoscopy Unit of Humanitas Clinical Institute, directed by prof. Alberto Malesci. From 2000 to 2006, he held the position of Assistant of the Gastroenterology and Digestive Endoscopy Unit of the Humanitas Clinical Institute. Since 2006 he has been Head of the Section of Emergency Gastroenterology and Head of Gastroenterology at the Humanitas Clinical Institute. He is Professor of Medicine and Surgery at the University of Milan.

1996-1997 Hospital of Niguarda, Milan, Italy
Assistant in the Gastroenterology and Digestive Endoscopy Services directed by Prof. Raffaele Arcidiacono

1987-1996 Polyclinic Hospital, Milan, Italy
Specialising in Gastroenterology in the Gastroenterology and Digestive Endoscopy service of the Institute of Internal Medicine directed by Prof. Nicola Dioguardi.
Volunteer medical specialist in the Gastroenterology and Digestive Endoscopy service in the Institute of Internal Medicine directed by Prof. Nicola Dioguardi.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=Omodei P

Prof. Arturo Chiti graduated in Medicine and Surgery at the University of Milan in 1989, and in the same year he entered the Post graduated School in Nuclear Medicine at the University of Milan, where he got his degree in 1993. In the same year he started working as Associate Chief at the National Cancer Institute in Milan, where he began his clinic and scientific experience in Oncology.
In 1997, he got the European Board of Nuclear Medicine fellowship.

In June 2000 he started leading the Nuclear Medicine Department at Humanitas Research Hospital.

On March 1, 2015 he was appointed Full Professor in Diagnostic Imaging and Radiotherapy at the Humanitas University in Milan, where he is also elected member of the Board.

Prof. Chiti is the Unit Director of the Nuclear Medicine Unit in Humanitas Research Hospital. He is the Director of the Post Graduate School in Diagnostic Imaging at Humanitas University. He is member of the Technical and Scientific Committee of the National Centre for Oncologic Adrotherapy (CNAO).

Arturo Chiti is co-author of several papers (www.scopus.com, www.pubmed.com) with an H-index of 30 (July 2016), wrote some books’ chapters and contributed to many abstracts presented at international and national meetings.
He is Honorary Editor of the European Journal of Nuclear Medicine and Molecular Imaging and reviewer for several international journals and grant applications.

He is a well-known invited speaker at numerous international congresses and conferences.

Prof. Arturo Chiti is the President of the European Association of Nuclear Medicine (EANM), where he has been active for more than 10 years.

He is also acting as an expert consultant for International Atomic Energy Agency (IAEA) and is member of the International Commission on Radiation Units and Measurements (ICRU).

He was awarded the honorary membership of the European Society for Therapeutic Radiology and Oncology (ESTRO); the Tom Miller Memorial Lecture Award from the Society of Nuclear Medicine and Molecular Imaging and the Hevesy Gyorgy award from the Hungarian Society of Nuclear Medicine.

Publications:

https://www.ncbi.nlm.nih.gov/pubmed/?term=chiti+arturo

Prof. Alberto Albanese is the Neurology Unit Director at Humanitas Research Hospital. Until recently – Department Head of Neuroscience at the Institute of Neurology Carlo Besta (Milan). In 1977 prof. Albanese received his degree in medicine and surgery, in 1981 – in neurology, and in 1985 – in psychiatry. His professional experience began with the founding of the Department of “disorders of Parkinson’s and violations of the musculoskeletal system” at the clinic “A. Gemelli “in Rome in 1984, which he led until 1996. From 1996 to 2000 prof. Albanese was the Head of the Neurological University Clinic of Lausanne (Switzerland) and a professor of Neurology in the University.

From 2000 to 2015 he was Head of Neuroscience Department at the Institute of Neurology Carlo Besta (Milan).

Prof. Albanese is a professor of neurology at the Institute of Neurology at the Catholic University of the Sacred Heart (Milan), Director of the post-graduate course “Diagnosis and treatment of movement disorders and degenerative neurological diseases” at the Foundation Neurological Institute “C. Besta”, as well as an adjunct professor at the School of Specialization in Neuroscience at the University of Milan Bicocca.

Prof. Albanese is the president of “Italian Association of Parkinson’s disease and movement disorders” and “Italian Association for the Study of the autonomic nervous system” (which are part of “Italian Community of Neuroscience”). He is also an honorary member of the “French Community of Neuroscience.” The professor is a moderator and speaker at major national and international neurological conferences, he organized several symposia dedicated to Neurology, collaborates with numerous national and international research centers, which are studying Parkinson’s disease, movement disorders and degenerative neurological diseases. Prof. Albanese has been repeatedly receiving research fundings from the following government agencies: the Ministry of Health, Ministry of Science and Research, National Research Council, the British Council, the Swiss National Research Council.

He is one of the greatest Italian experts on the diagnosis and treatment of neurological diseases and movement disorders, Parkinson.

He has extensive experience in the use of neurostimulation of brain neurological movement disorders, for treating Parkinson’s disease and other involuntary movements.

He developed the first Italian project on the study of genetic disease and Parkinson’s dystonia, which led to the discovery of two new genetic loci. Also prof. Albanese is actively engaged in research in the field of semiotics detailed definition of involuntary movements, which allows tracking of related clinical pathology for accurate diagnosis of patients with movement disorders.

Prof. Albanese has published more than 200 scientific papers, most of which are published in indexed journals (with a total impact factor>500), is the author of one monograph, 3 books and co-author of numerous books and publications. He is the chief editor of “Frontiers in Movement Disorders” and assistant editor of the “European Journal of Neuroscience”.

Publications: http://www.ncbi.nlm.nih.gov/pubmed?term=albanese a

Prof. Alessandro Castagna is the Orthopedic Surgery of the Shoulder and Elbow Unit Director in Humanitas Research Hospital. He performs both traditional surgeries and arthroscopic surgeries. He developed experience in arthroscopic surgery of the shoulder in the United States where he studied at the Southern California Orthopedic Institute, under the guidance of Dr. Stephen J. Snyder (famous shoulder surgeon, inventor and co-developer of surgical tools for shoulder arthroscopy).

Prof. Castagna gained experience in open surgery of the shoulder under the guidance of Prof. Mario Randelli, founder and past-president of the Italian Society for Surgery of the Shoulder, in Milan (Italy). He has specialized almost exclusively in shoulder surgery for more than 25 years and counts over 40.000 cases in his career. He carries out about 900 surgeries per year, including total shoulder prostheses, reverse prostheses, open and arthroscopic stabilization, rotator cuff repair and proximal humerus fractures.

Research areas of interest: 

Improvement of surgical and therapeutic methods of shoulder pathology. He gives particular attention to the study of biological and functional aspects with the development of surgical techniques, materials and dedicated tools. 

Teaching experience: Adjunct Professor at the Orthopedics Course of Specialization in Diseases of the Locomotor System at the University of L'Aquila.

Scientific activity: 

Prof. Castagna was president of European Society for Surgery of the Shoulder and the Elbow (ESSSE/SECEC) (www.secec.org) from 2012 to 2014 and president of Italian Society for Surgery of the Shoulder and Elbow (SICS&G) (www.sicseg.it) from 2010 to 2012. He is also a Member of the Board di International Congress of Shoulder and Elbow Surgery (ICSES, www.icses.org) nominated for the period from 2013 to 2022.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=castagna+alessandro

Prof. Alessio Michele Goffredo Aghemo is the Hepatology Unit Director in Humanitas research Hospital.

Medical areas of interest: 

• liver diseases
• viral hepatitis
• metabolic hepatitis
• liver cirrhosis

Previous experience: 

From 2007 to 2017 he was the 1st level Medical Director at the U.O of Gastroenterology of the IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan.

Research areas of interest: 

Clinical and research activity focused on natural history and treatment of viral hepatitis.

He is the author of 155 peer-reviewed publications (Impact Factor total 1151.3, H-Index 25 according to Scopus, H-Index 20 last 5 years Scopus, H-Index 30 according to Google Scholar) (updated September 2017).

From 2013 to 2016 he was a scientific member of the governing board of the European Association for the Study of the Liver (EASL).

Since 2016 he is a member of the scientific committee of the European Association of Gastroenterology (UEG).

He is a member of the AISF (Italian Association for the Study of the Liver) commission for antiviral drugs directed against HCV (2012-present). Since 2016 he has been the coordinator of the same. 

He was AIFA/EMEA expert for liver disease since 2008.

Member of the Executive Committee of the HCV Regional Network, determined by the Lombardy Region on 28 September 2015.

He participated as an expert in the drafting of the European Guidelines 2013-2014-2015-2016-2017 (EASL) and Italian (AISF) on the Treatment of Chronic Hepatitis C.

Teaching experience:

He is associated professor of Gastroenterology at Humanitas University since September 2017.

Prof. Antonio Costanzo is the Dermatology Unit Director in Humanitas Research Hospital. He graduated with his MD degree in Medicine and Surgery from the University of Rome, La Sapienza in 1994. He then went on to complete post-graduate study and received a speciality degree in Internal Medicine in 1999 and a Dermatology speciality degree in 2006.

Medical areas of interest:

• Inflammatory and autoimmune skin diseases (Psoriasis, Atopic Dermatitis, Alopecia Areata, Chronic Urticaria, Suppurative Hydroadenitis, Scleroderma, Lupus)
• Personalized Medicine, Biological Psoriasis Therapy
• Dermatological Oncology (Melanoma, Actinic Keratosis, Basocellular and Spinocellular Epitheliomas).
• Prevention of skin neoplasms (dermatoscopy, computer mapping of moles).
• Dermatological surgery

Previous experience:

• Director of Dermatology Unit at Sant’Andrea Hospital in Vercelli
• University Researcher/Hospital Assistant at Tor Vergata Hospital 

Research areas of interest: 

• Psoriasis pathogenesis of other inflammatory and autoimmune skin diseases
• Pathogenesis of skin neoplasms
• Genetic disorders of the skin

His clinical research is focused on the characterization of the activity of biologics in psoriasis and psoriatic arthritis. This research is strictly linked to basic research activity on the pathogenesis of psoriasis and on the use of pharmacogenetic approach to predict the efficacy and safety of biologics in psoriasis.

In the past, Professor Costanzo has collaborated to the characterization of basic mechanisms of TNF inflammatory signalling in epithelial cells and NFkappaB regulation by different stimuli. More recently his research group has collaborated to the discovery of IL-21 as critical mediator of keratinocyte proliferation in psoriasis. Professor Costanzo has authored or co-authored more than 120 publications in internationally peer-reviewed journals.

Teaching experience: Full Professor of Dermatology at Humanitas University

Publications: https://www.ncbi.nlm.nih.gov/pubmed/?term=Costanzo+A 

Prof. Bruno Bernardini is the Neurological Rehabilitation Unit Director in Humanitas Research Hospital. 

Medical areas of interest:

Rehabilitation in acute-subacute phase of disabled patients for neurological diseases (stroke, cranial-encephalic and medullary trauma, tumors of the nervous system, neuropathies). Hospital risk of fragile elderly patients. Orthogeriatrics.

Research areas of interest:
Post-operative rehabilitation indicators and process-outcome measures for patient prognostic stratification and clinical performance evaluation. 

He is the coordinator of a multicentre study for the application of process-outcome indicators in rehabilitation. The study involves hospital and extra-hospital facilities in Lombardy, Liguria and other regions of Central and Northern Italy.

Previous experience:

2005-2007 Galliera Hospital Authority, Genoa, Italy

Director of the Functional Recovery structure.

Member of the work group for defining the Regional Plan of rehabilitation work 2006-2009 in the Liguria region.

Evaluation, treatment and facilitation of care processes in patients in Neurology, Intensive Care, Neuro-surgery, Intermediate Care, Orthopaedic and Home Care. 

Outpatient work as a physiatric specialist, with a specific sector on the rehabilitation of the pelvic floor.

Development of processes in diagnostic and therapeutic hospital care (especially lumbar-sciatica, joint replacements, cardiac failure, femur fractures and most fast-track urological operations).

1988-1995 Hospital of Niguarda, Milan, Italy
Visiting doctor at the Centre for High Specialisation in Allergology and Clinical Immunology with full-time specialisation in the Department of Pneumology Piazza.

Teaching experience: Medicine Professor at the University of Genoa.

Scientific activities: Member of the board of directors and Geriatric area contact person at “Italian Urodynamic Society Continence, Neuro-Urology, Pelvic Floor”

Prof. Romano Lutman is the Head Oncological and interventional radiology Unit.

Medical areas of interest: 
diagnostic and interventional oncology, in particular linked to percutaneous imaging-guided procedures.
He has performed over 3000 CT guided lung biopsies and numerous international trials on anticancer drugs.

Research areas of interest: 
advanced oncological diagnostics. Percutaneous minimally invasive imaging-guided diagnostic and therapeutic procedures in oncology.

Previous experience:  
- 1991-1996 Orthopaedic Institute of Gaetano Pini, Italy
Assistant Physiatrist
- 1991-1991 Hospital of the Piemonte region , Italy
Specialist doctor in sports medicine

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=lutman r

Dott. Antonio Frontera is the Electrophysiology Unit Director in Humanitas Research Hospital.  

Medical areas of interest: 

After graduating in Medicine and Surgery at the University Cattolica del Sacro Cuore in Rome in 2006, he specialized in Cardiology at the same university in 2012.

Soon after his specialization he moved to England where he was hired as a Clinical and Research Fellow in cardiac electrophysiology at the Bristol Heart Institute (NHS), Bristol. 
He won a scholarship from the European Society of Aritmology (EHRA) and completed his training in cardiac electrophysiology at the prestigious Haut Léveque Hospital in Bordeaux, France, directed by Prof. Michel Haïssaguerre. In the same French university, he obtained his PhD.

During these 5 years of training abroad, he performed about 800 trans catheter ablation surgeries focusing mainly on the treatment of supraventricular arrhythmias. As a researcher, he has published nearly 100 scientific papers on innovation and trans catheter ablation techniques, defibrillator and pacemaker functioning algorithms.

Back to Italy, he was employed at the Aritmology Unit of the San Raffale Hospital specializing in the treatment of ventricular tachycardia, performing more than 150 procedures as a first and second operator.

To date, Dr. Frontera is the author of more than 145 scientific papers published in international journals. He constantly participates in national and international congresses of the sector.

Research areas of interest:
He has particular interest in the analysis of endocavitary signals (EGMs) in ventricular tachycardia and atrial fibrillation.

Thanks to a close collaboration with the Mathematics department of Politecnico di Milano, directed by Prof. Quarteroni, he studied innovative techniques for the treatment of complex arrhythmias.

Previous experience:
 

• Clinical and Research Fellow in Cardiac Electrophysiology - Bristol Heart Institute, Bristol, UK
• Clinical and Research Fellow in Cardiac Electrophysiology - Hôpital Haut Léveque, Bordeaux, FR

Publications: 

Sinus node exit, crista terminalis conduction, interatrial connection and wavefront collision: key features of human atrial activation in sinus rhythm.
Pambrun T, Derval N, Duchateau J, Ramirez FD, Chauvel R, Tixier R, Marchand H, Bouyer B, Welte N, André C, Nakashima T, Nakatani Y, Kamakura T, Takagi T, Krisai P, Ascione C, Balbo C, Cheniti G, Vlachos K, Bourier F, Takigawa M, Kitamura T, Frontera A, Meo M, Denis A, Sacher F, Hocini M, Jaïs P, Haïssaguerre M.Heart Rhythm. 2022 Jan 13

Electrogram fractionation during sinus rhythm occurs in normal voltage atrial tissue in patients with atrial fibrillation.
Frontera A, Limite LR, Pagani S, Cireddu M, Vlachos K, Martin C, Takigawa M, Kitamura T, Bourier F, Cheniti G, Pambrun T, Sacher F, Derval N, Hocini M, Quarteroni A, Della Bella P, Haissaguerre M, Jaïs P.Pacing Clin Electrophysiol. 2021

Slow Conduction Corridors and Pivot Sites Characterize the Electrical Remodeling in Atrial Fibrillation - ScienceDirect
Antonio Frontera MD, Ph.D1, Stefano Pagani Ph.D2, Luca Rosario Limite MD1, Andrea Peirone MD1, Francesco Fioravanti MD1, Bogdan Enache MD6, Jose Cuellar, MD4, Konstantinos Vlachos, MD5, Christian Meyer, MD, MA7, Giovanni Montesano, MD8, Andrea Manzoni, Ph.D2, Luca Dedè2 Ph.D2, Alfio Quarteroni, Ph.D2,3, Decebal Gabriel Lațcu, MD6, Pietro Rossi MD, Ph.D9, Paolo Della Bella MD1.
JACC EP Jan 2022

Right ventricular outflow tract electroanatomical abnormalities in asymptomatic and high-risk symptomatic patients with Brugada syndrome: Evidence for a new risk stratification tool?
Letsas KP, Vlachos K, Conte G, Efremidis M, Nakashima T, Duchateau J, Bazoukis G, Frontera A, Mililis P, Tse G, Cheniti G, Takigawa M, Pambrun T, Prappa E, Sacher F, Derval N, Sideris A, Auricchio A, Jais P, Haissaguerre M, Hocini M.J Cardiovasc Electrophysiol. 2021

Effect of electrode size and spacing on electrograms: Optimized electrode configuration for near-field electrogram characterization.
Takigawa M, Kitamura T, Basu S, Bartal M, Martin CA, Martin R, Cheniti G, Vlachos K, Pillois X, Frontera A, Massoullié G, Thompson N, Bourier F, Lam A, Duchateau J, Pambrun T, Denis A, Derval N, Cochet H, Haïssaguerre M, Sacher F, Hocini M, Jaïs P.Heart Rhythm. 2022 Jan;