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До самої процедури приступають після того, як більшість пухлини вже видалена.</p>\n\n<p style=\"text-align:justify;\">Стерилізований розчин протипухлинного препарату розігрівається до 42°С та вливається в черевну порожнину пацієнта. По порожнині він циркулює протягом 1,5 години. За цей час медичний препарат взаємодіє безпосередньо з раковими клітинами, що залишилися, знищуючи їх.</p>\n\n<p style=\"text-align:justify;\">Наприкінці процедури розчин зливається, а черевна порожнина зашивається.</p>\n\n<p style=\"text-align:justify;\">Гіпертермічна внутрішньочеревна хіміотерапія знищує ракові клітини, які не зміг видалити хірурга.</p>\n\n<div>\n<p style=\"text-align:justify;\"><strong>Навіщо нагрівати препарат, що вводиться?</strong></p>\n\n<p style=\"text-align:justify;\">Процедура гарячої хіміотерапії дозволяє доставляти великі дози протипухлинних препаратів безпосередньо до ракових клітин. Позитивний ефект цього методу лікування досягається також завдяки підвищеній температурі розчину, що вводиться.</p>\n</div>\n</div>\n\n<h2>Основні переваги HIPEC:</h2>\n\n<div class=\"accordion-item-text\">\n<ul class=\"list\">\n\t<li>розігрітий препарат знищує злоякісні клітини, не торкаючись при цьому здорових;</li>\n\t<li>доза гарячого препарату, що вводиться, може бути набагато вище, ніж при інших способах введення хіміотерапії;</li>\n\t<li>розігрітий препарат майже не потрапляє у кров, що знижує ризик виникнення побічних ефектів;</li>\n\t<li>ракові клітини більш сприйнятливі до нагрітого препарату;</li>\n\t<li>ліки можуть проникати глибше в пухлину.</li>\n</ul>\n</div>\n\n<h2>Вартість хіміотерапії HIPEC</h2>\n\n<div class=\"accordion-item-text\">\n<p style=\"text-align:justify;\">\"Гарячу хімію\" або гіпертермічну хіміотерпію проводять 1 раз під час операції, тому вартість процедури вказується разом із вартістю хірургічного втручання.</p>\n\n<p style=\"text-align:justify;\">Гіпертермічна хіміотерапія добре переноситься пацієнтами та майже не має протипоказань. Найчастіше вона застосовується тоді, коли інші методи лікування виявилися неефективними.</p>\n</div>"},"guide_mc":{"text":"<p>День 1</p><ul><li> Прибути в призначену лікарню.</li><li> Заселення на рецепції.</li><li> Зустріньтеся з лінгвістичним асистентом, якщо необхідно.</li></ul><p> день 2</p><ul><li> Проконсультуватися з онкологами, анестезіологами, хірургами.</li><li> Провести трансвагінальне УЗД.</li><li> Пройти інші необхідні дослідження за призначенням спеціалістів.</li></ul><p> день 3</p><ul><li> Отримати передопераційні інструкції.</li><li> Підготуйтеся до процедури HIPEC.</li></ul><p> День 4</p><ul><li> Пройдіть процедуру HIPEC під загальним наркозом.</li><li> Процедура триває близько 6-8 годин.</li></ul><p> З 5 по 14 день</p><ul><li> Післяопераційний догляд в стаціонарі.</li><li> Слідкуйте за відновленням і контролюйте будь-які побічні ефекти.</li></ul><p> З 3 по 6 тиждень</p><ul><li> Почніть реабілітацію вдома або в спеціальному закладі.</li><li> Поступово повертайтеся до нормальної діяльності.</li></ul><p> 7 тиждень і далі</p><ul><li> По можливості поверніться на роботу або в школу.</li><li> Відновіть заняття спортом та інші фізичні навантаження, якщо ви переносите.</li></ul><p> <i>Зверніть увагу, що терміни відновлення кожного пацієнта можуть відрізнятися залежно від індивідуального стану здоров’я та реакції на лікування.</i></p>"},"overview":{"text":"<h3>Гіпертермічна внутрішньочеревна хіміотерапія (HIPEC)</h3> <p>HIPEC включає в себе доставку нагрітої хіміотерапії безпосередньо в черевну порожнину для лікування раку.</p> <div>[icon-pros<b>]Плюси:</b><span> HIPEC дає змогу більш ефективно впливати на ракові клітини в черевній порожнині порівняно із системною хіміотерапією. Він показав 50-відсоткове збільшення виживаності при деяких видах раку.</span></div> <div>[icon-cons<b>]Мінуси:</b><span> Ця процедура може призвести до більш безпосередніх побічних ефектів, таких як біль у животі, і вимагає госпіталізації для спостереження. Підходить тільки для ракових пухлин, розташованих у очеревинній порожнині.</span></div> <div>[icon-effect<b>]Ефективність:</b><span> 70 % успіху в збільшенні виживаності пацієнтів при певних видах раку очеревини.</span></div> <div>[icon-clock<b>]Тривалість:</b><span> 6-12 годин.</span></div> <div>[icon-run<b>]Відновлення:</b><span> 4-6 тижнів.</span></div> <div>[icon-thumbs<b>]Найкраще підходить для:</b><span> Карциноматоз очеревини і пухлини черевної порожнини, особливо колоректального і яєчникового походження.</span></div> <div>[icon-price<b>]Ціни:</b><span> [txt-country]</span></div>"}}},"articles":[{"id":"ua:affordable-hipec-advanced-cancer-treatment-for-less","name":"HIPEC може бути доступною: передове лікування раку за вигідною ціною","image":{"main":"https://bookimed.s3.eu-central-1.amazonaws.com/articles/67c1_b.jpeg","preview":"https://bookimed.s3.eu-central-1.amazonaws.com/articles/67c1_s.jpeg"},"author":{"first_name":"Kateryna","last_name":"Zamkovska","avatar":"https://s3.eu-central-1.amazonaws.com/bookimed/admin/66ab3953e4c4e_b.jpeg"}}],"relations":{"countries":[{"name":"Ізраїль","alias":"israel","iso_code":"IL"},{"name":"Індія","alias":"india","iso_code":"IN"},{"name":"Іспанія","alias":"spain","iso_code":"ES"},{"name":"Італія","alias":"italy","iso_code":"IT"},{"name":"Азербайджан","alias":"azerbaijan","iso_code":"AZ"},{"name":"Греція","alias":"greece","iso_code":"GR"},{"name":"Китай","alias":"china","iso_code":"CN"},{"name":"Малайзія","alias":"malaysia","iso_code":"MY"},{"name":"Німеччина","alias":"germany","iso_code":"DE"},{"name":"Південна Корея","alias":"republic-of-korea","iso_code":"KR"},{"name":"Таїланд","alias":"thailand","iso_code":"TH"},{"name":"Туреччина","alias":"turkey","iso_code":"TR"},{"name":"Україна","alias":"ukraine","iso_code":"UA"}],"cities":[{"name":"Салоніки","alias":"thessaloniki"}],"operations":[{"name":"Мастектомія","alias":"mastectomy"},{"name":"Видалення нирки лапароскопічне","alias":"laparoscopic-nephrectomy"},{"name":"Хіміотерапія","alias":"chemotherapy"},{"name":"Резекція щитовидної залози","alias":"thyroid-resection"},{"name":"Резекція при раку печінки","alias":"removal-of-liver-cancer"},{"name":"Операція при раку товстого кишечника","alias":"removal-of-colon-cancer"},{"name":"Видалення пухлини головного мозку","alias":"removal-of-the-brain-tumor"},{"name":"Простатектомія","alias":"prostatectomy"},{"name":"Радіочастотна абляція","alias":"radiofrequency-ablation"},{"name":"Видалення пухлини спинного мозку","alias":"removal-of-spinal-cord-tumor"},{"name":"Видалення 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простатектомія","alias":"laparoscopic-prostatectomy"},{"name":"Хіміотерапія при раку легень","alias":"chemotherapy-for-lung-cancer"},{"name":"Хіміотерапія при раку простати","alias":"chemotherapy-for-prostate-cancer"},{"name":"Променева терапія при раку простати","alias":"radiotherapy-for-prostate-cancer"},{"name":"Імунотерапія при раку простати","alias":"immunotherapy-for-prostate-cancer"},{"name":"Променева терапія при раку легень","alias":"radiotherapy-for-lung-cancer"},{"name":"Гормонотерапія при раку простати","alias":"hormone-therapy-for-prostate-cancer"},{"name":"Променева терапія при раку молочної залози","alias":"radiotherapy-for-breast-cancer"},{"name":"Променева терапія при раку матки","alias":"radiotherapy-for-uterine-cancer"},{"name":"Променева терапія при раку шийки матки","alias":"radiotherapy-for-cervical-cancer"},{"name":"Хіміотерапія при раку матки","alias":"chemotherapy-for-uterine-cancer"},{"name":"Хіміотерапія при раку 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strenuous exercise and heavy lifting only after surgical clearance."},"final_result_months":{"min":3,"max":6,"unit":"months","qualifier":"Time to first surveillance imaging and functional recovery; oncologic outcome depends on tumour type and completeness of cytoreduction."},"fly_home_after_days":{"min":14,"max":28,"unit":"days","qualifier":"Counted from surgery; after discharge, bowel function return, and surgeon clearance; longer with complications or thrombosis risk."},"follow_up_visits":[{"purpose":"wound_check","requirement":"routine","after":{"min":14,"max":28,"unit":"days","qualifier":"Post-discharge surgical review"}},{"purpose":"assessment","requirement":"routine","after":{"min":30,"max":60,"unit":"days","qualifier":"Oncology review and adjuvant planning"}},{"purpose":"result_review","requirement":"routine","after":{"min":90,"max":120,"unit":"days","qualifier":"Typical first surveillance imaging and tumour markers, then periodic"}}],"indications":["Peritoneal metastases from appendiceal cancer or pseudomyxoma peritonei","Peritoneal mesothelioma","Selected colorectal peritoneal metastases","Selected ovarian cancer with peritoneal disease","Selected gastric cancer peritoneal disease"],"main_risks":["Anastomotic leak or bowel fistula","Intra-abdominal infection or abscess","Bleeding","Postoperative ileus or bowel obstruction","Pancreatitis","Venous thromboembolism","Pulmonary complications and pleural effusion","Renal toxicity and electrolyte disturbances","Myelosuppression","Prolonged hospitalization or need for reoperation","Perioperative mortality"],"pain":"Moderate to severe pain after major abdominal surgery in the first days, managed with multimodal analgesia (often epidural or regional blocks plus medication), then gradually improving.","preparation":["Multidisciplinary tumour board review","Staging CT/MRI and tumour markers; sometimes diagnostic laparoscopy","Cardiopulmonary, renal and hepatic fitness assessment and blood tests","Nutritional assessment and optimisation","Anaesthetic and ICU planning","Fasting and bowel preparation as instructed","Stoma counselling where relevant","Smoking cessation and informed consent"],"recovery_timeline":[{"phase":"Days 0-3","description":"ICU or high-dependency monitoring, pain control, fluid and electrolyte management.","restrictions":["Bed rest with assisted mobilisation","Nothing by mouth initially"]},{"phase":"Days 4-21","description":"Gradual return of bowel function and diet, drain removal, mobilisation, discharge when stable.","restrictions":["No lifting","Dietary progression"]},{"phase":"Weeks 3-8","description":"Home recovery, fatigue improving, wound healing, nutrition rebuilding; possible adjuvant chemotherapy planning.","restrictions":["Avoid heavy lifting and strenuous activity"]},{"phase":"Months 2-4","description":"Return to ordinary activities and work for many patients; start of surveillance.","restrictions":["Gradual increase in activity as tolerated"]}],"rehabilitation_days":{"min":42,"max":90,"unit":"days","qualifier":"Ordinary functional recovery after cytoreductive surgery with HIPEC; fatigue may persist longer."},"result_longevity":"Benefit is disease control, not cure for all. Durability varies by tumour type and completeness of cytoreduction; some patients remain disease-free for years, others recur and need surveillance.","revision_rate_pct":{"min":5,"max":15,"unit":"percent","qualifier":"Unplanned return to theatre within 30-90 days, e.g. for leak, bleeding or abscess"},"scars":"Long midline abdominal incision (xiphoid to pubis) is typical, plus drain sites; a stoma may be needed in some patients.","sessions_or_stages":{"sessions":{"min":1,"max":1,"unit":"visits","qualifier":"One combined operation: cytoreductive surgery followed by HIPEC perfusion."},"stages":[{"code":"cytoreduction","label":"Cytoreductive surgery removing visible tumour and affected tissue","after":{"min":0,"max":0,"unit":"days","qualifier":"Same operation"}},{"code":"hipec_perfusion","label":"Heated intraperitoneal chemotherapy perfusion (typically 30-90 minutes)","after":{"min":0,"max":0,"unit":"days","qualifier":"Same operation, after cytoreduction"}},{"code":"reconstruction","label":"Bowel reconstruction or closure","after":{"min":0,"max":0,"unit":"days","qualifier":"Same operation"}}],"qualifier":"Single operative session with sequential stages."},"success":{"metric":"5-year overall survival after complete cytoreduction with HIPEC","value":50,"unit":"percent","horizon":"5 years","population":"Adults with peritoneal metastases, mixed tumour types, complete or near-complete cytoreduction","evidence_status":"limited"},"techniques":[{"name":"Open (coliseum) HIPEC with cytoreductive surgery","suits_whom":"Patients with peritoneal surface malignancy where abdomen is kept open during perfusion for uniform heat distribution and surgeon access.","recovery":"Inpatient stay of about 10-21 nights; recovery over several weeks to months."},{"name":"Closed-abdomen HIPEC with cytoreductive surgery","suits_whom":"Patients with peritoneal surface malignancy where the abdomen is closed before perfusion to maintain temperature and reduce exposure.","recovery":"Similar to open technique: about 10-21 nights inpatient and recovery over weeks to months."}],"treatment_conditions":["inpatient"],"treatment_duration_hours":{"min":6,"max":12,"unit":"hours","qualifier":"Complete operation, cytoreductive surgery plus HIPEC perfusion; varies with disease extent."},"initial_assessment_documents":["Histopathology report of primary tumour or biopsy","Contrast CT of chest, abdomen and pelvis","Abdominopelvic MRI report","Tumour marker blood results","Previous operative and chemotherapy reports","Recent kidney and liver function blood tests"],"travel_trips":{"min":1,"max":1,"one_trip_possible":true,"qualifier":"Single combined operation; about 10-21 nights inpatient until discharge and fitness to fly. Surveillance usually at home."},"clinic_checks":{"status":"ok","items":[{"id":"C1","text":"Check the surgeon's established track record with these complex operations. Why: the operation is complex, so experience matters","scope":"procedure","source":{"url":"https://stonybrookmedicine.edu/node/2289","host":"stonybrookmedicine.edu","quote":"Patients should seek surgeons with established track records of performing these complex operations.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C2","text":"Check the qualifications of the medical team that will treat you","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Have you checked the qualifications of the medical team treating you?","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C3","text":"Get a second opinion from a doctor at home on whether the treatment is necessary and what options exist","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"A doctor can give you a valuable second opinion as well as advice about treatment options and whether it's necessary.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C4","text":"Find out whether follow-up care is scheduled at the same facility as the procedure","scope":"treatment_abroad","source":{"url":"https://www.cdc.gov/yellow-book/hcp/health-care-abroad/medical-tourism.html","host":"cdc.gov","quote":"Medical tourists should also know whether follow-up care is scheduled to occur at the same facility as the procedure.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":403}},{"id":"C5","text":"Confirm the surgeon is trained and experienced in the exact procedure you are considering, not just in surgery generally","scope":"treatment_abroad","source":{"url":"https://www.isaps.org/discover/patients-home/considering-your-procedure-abroad/finding-a-surgeon-abroad/","host":"isaps.org","quote":"Verify that the surgeon is trained and experienced in performing the procedure you are considering.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"red_flags":{"status":"ok","items":[{"id":"F1","text":"Pressure to make a quick decision about booking treatment abroad","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"pressure to make a quick decision","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"F2","text":"Booking advice from sales staff or travel agents is a red flag","scope":"treatment_abroad","source":{"url":"https://travelhealthpro.org.uk/news/699/travelling-abroad-for-treatment","host":"travelhealthpro.org.uk","quote":"Do not accept advice from a travel agent, sales representatives or administrators.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"F3","text":"Being unable to speak directly with the treating clinician before booking is a red flag","scope":"treatment_abroad","source":{"url":"https://travelhealthpro.org.uk/news/699/travelling-abroad-for-treatment","host":"travelhealthpro.org.uk","quote":"Speak directly to the doctor, dentist or nurse who will be carrying out your treatment before you book your trip.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"F4","text":"Being denied the chance to change your mind during the consultation is a red flag","scope":"treatment_abroad","source":{"url":"https://travelhealthpro.org.uk/news/699/travelling-abroad-for-treatment","host":"travelhealthpro.org.uk","quote":"You should be given the opportunity to change your mind during this consultation.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"warning_signs":{"status":"ok","items":[{"id":"W1","text":"Severe swelling, warmth or drainage at the incision","urgency":"contact_clinic","general":false,"source":{"url":"https://my.clevelandclinic.org/health/treatments/21569-hyperthermic-intraperitoneal-chemotherapy-hipec","host":"my.clevelandclinic.org","quote":"Severe swelling, warmth or drainage around your incision site","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"W2","text":"Nausea and vomiting that do not improve","urgency":"contact_clinic","general":false,"source":{"url":"https://my.clevelandclinic.org/health/treatments/21569-hyperthermic-intraperitoneal-chemotherapy-hipec","host":"my.clevelandclinic.org","quote":"Nausea and vomiting that don’t improve","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"W3","text":"Fever above 101 degrees F (38.3 degrees C)","urgency":"contact_clinic","general":true,"source":{"url":"https://my.clevelandclinic.org/health/treatments/21569-hyperthermic-intraperitoneal-chemotherapy-hipec","host":"my.clevelandclinic.org","quote":"Fever above 101 degrees F (38.3 degrees C)","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"take_home":{"status":"ok","items":[{"id":"T1","text":"Gives the home doctor treatment details and future care needs","document":"discharge letter for 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for copies of all your treatment records, including prescriptions, scans and x-rays before you leave.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"T4","text":"Home doctor needs the dates for required blood tests and follow-up appointments","document":"written aftercare plan","source":{"url":"https://sbuhb.nhs.wales/about-us/individual-patient-commissioning/ipc-folder/advice-on-accessing-treatment-abroad","host":"sbuhb.nhs.wales","quote":"This should include any medication and doses, as well as any dates that blood tests and follow-up appointments must be carried out.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"alternatives":{"status":"ok","items":[{"id":"A1","text":"You would rather have several rounds of chemotherapy","name":"Systemic 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